The CLUSTAL_X windows interface : flexible strategies for multiple sequence alignment aided by quality analysis tools

Testo completo ad accesso aperto Verifica disponibilità: Testo completo (sito dell'editore)

Abstract

CLUSTAL X is a new windows interface for the widely-used progressive multiple sequence alignment program CLUSTAL W. The new system is easy to use, providing an integrated system for performing multiple sequence and profile alignments and analysing the results. CLUSTAL X displays the sequence alignment in a window on the screen. A versatile sequence colouring scheme allows the user to highlight conserved features in the alignment. Pull-down menus provide all the options required for traditional multiple sequence and profile alignment. New features include: the ability to cut-and-paste sequences to change the order of the alignment, selection of a subset of the sequences to be realigned, and selection of a sub-range of the alignment to be realigned and inserted back into the original alignment. Alignment quality analysis can be performed and low-scoring segments or exceptional residues can be highlighted. Quality analysis and realignment of selected residue ranges provide the user with a powerful tool to improve and refine difficult alignments and to trap errors in input sequences. CLUSTAL X has been compiled on SUN Solaris, IRIX5.3 on Silicon Graphics, Digital UNIX on DECstations, Microsoft Windows (32 bit) for PCs, Linux ELF for x86 PCs, and Macintosh PowerMac.

Salvato in:
Autori: Julie Thompson iD (Centre National de la Recherche Scientifique; Inserm; Institut de génétique et de biologie moléculaire et cellulaire)
Pubblicato in: Nucleic Acids Research, vol. 25, n. 24, pp. 4876-4882
Data di pubblicazione:15/12/1997
Editore:Oxford University Press
Tipo di documento:Articolo
Lingua:inglese
DOI: 10.1093/nar/25.24.4876
ISSN:0305-1048, 1362-4954, 1362-4962
Accesso aperto: Accesso aperto Bronze: lettura gratuita presso l'editore, senza licenza aperta – Nucleic Acids Research
Citazioni ricevute:39.013
Soggetti:
Genomics and Phylogenetic Studies (Life Sciences > Biochemistry, Genetics and Molecular Biology > Molecular Biology)
Fractal and DNA sequence analysis (Life Sciences > Biochemistry, Genetics and Molecular Biology > Molecular Biology)
Genetics, Bioinformatics, and Biomedical Research (Life Sciences > Biochemistry, Genetics and Molecular Biology > Molecular Biology)
multiple sequence alignment, progressive alignment, profile alignment, alignment refinement
Identificativi: OpenAlex W2097382368 · PMID 9396791

Dati dell'indice centrale: OpenAlex (licenza CC0).

Riassunto:CLUSTAL X is a new windows interface for the widely-used progressive multiple sequence alignment program CLUSTAL W. The new system is easy to use, providing an integrated system for performing multiple sequence and profile alignments and analysing the results. CLUSTAL X displays the sequence alignment in a window on the screen. A versatile sequence colouring scheme allows the user to highlight conserved features in the alignment. Pull-down menus provide all the options required for traditional multiple sequence and profile alignment. New features include: the ability to cut-and-paste sequences to change the order of the alignment, selection of a subset of the sequences to be realigned, and selection of a sub-range of the alignment to be realigned and inserted back into the original alignment. Alignment quality analysis can be performed and low-scoring segments or exceptional residues can be highlighted. Quality analysis and realignment of selected residue ranges provide the user with a powerful tool to improve and refine difficult alignments and to trap errors in input sequences. CLUSTAL X has been compiled on SUN Solaris, IRIX5.3 on Silicon Graphics, Digital UNIX on DECstations, Microsoft Windows (32 bit) for PCs, Linux ELF for x86 PCs, and Macintosh PowerMac.
ISSN:0305-1048
1362-4954
1362-4962
DOI:10.1093/nar/25.24.4876